Core Insights - Palisade Bio has appointed Dr. Laurent Peyrin-Biroulet and Dr. David T. Rubin to its Clinical Advisory Board, enhancing its clinical strategy as it advances PALI-2108 towards Phase 2 development in ulcerative colitis and fibrostenotic Crohn's disease [1][2] Company Overview - Palisade Bio, Inc. is a clinical-stage biopharmaceutical company focused on developing next-generation oral PDE4 inhibitor prodrugs aimed at targeted delivery to the terminal ileum and colon [1][10] - The lead program, PALI-2108, is designed for once-daily oral administration and is pharmacologically inactive until it reaches the lower intestine, where it is activated by bacterial enzymes [9][11] Clinical Development - PALI-2108 has shown a 100% clinical response in a Phase 1b trial for ulcerative colitis, with no serious adverse events reported [11] - The company plans to submit an IND for a Phase 2 clinical study in ulcerative colitis in the first half of 2026, focusing on clinical remission and pharmacodynamic biomarkers over a 12-week period [1][12] Advisory Board Expertise - Dr. Peyrin-Biroulet is a leading authority in inflammatory bowel disease, with over 1200 peer-reviewed publications and significant roles in major IBD organizations [4][5] - Dr. Rubin is recognized for his expertise in clinical trial design and has been instrumental in the development of numerous approved IBD therapies [7][8]

BERKELEY HEIGHTS, N.J., Jan. 29, 2026 (GLOBE NEWSWIRE) -- CorMedix Therapeutics (Nasdaq: CRMD), a biopharmaceutical company focused on developing and commercializing therapeutic products for life-threatening diseases and conditions, today announced that it will host an in-person and virtual analyst day in New York on Tuesday, February 10, 2026 with presentations and panels from 1:00 PM to 3:00 PM Eastern. The Company will share background and updates across its portfolio and pipeline, and outline the busine ...

Core Insights - Aprea Therapeutics announced the first unconfirmed partial response (uPR) in a patient from its Phase 1 ACESOT-1051 study, indicating early clinical activity of APR-1051 in treating advanced solid tumors [1][2] Group 1: Clinical Trial Results - The uPR was observed in a patient with PPP2R1A-mutated uterine serous carcinoma, showing a 50% reduction in target lesion size and a decrease in CA-125 levels from 732 to 70 U/mL after treatment with APR-1051 at the 150 mg dose level [2][7] - Earlier cohorts in the ACESOT-1051 study reported stable disease in multiple patients, including a 5% reduction in tumor burden in a patient with HPV-positive head and neck squamous cell carcinoma and a 15% reduction in a patient with FBXW7-mutated colon cancer [3] - The ongoing dose-escalation study is currently enrolling patients in the 220 mg cohort, with plans to increase enrollment of HPV-positive patients [4][6] Group 2: Drug Mechanism and Strategy - APR-1051 is a small-molecule inhibitor of WEE1 kinase, designed to exploit cancer-specific vulnerabilities while minimizing damage to healthy cells [8][9] - The company aims to target cancers with specific genomic alterations, including mutations in PPP2R1A, FBXW7, CCNE1, TP53, and KRAS, reinforcing the potential of APR-1051 as a differentiated treatment option [5] Group 3: Future Outlook - Aprea Therapeutics plans to provide additional updates in the first half of 2026 and complete dose escalation later in the year, indicating ongoing commitment to the development of APR-1051 [5]

Core Viewpoint - Aprea Therapeutics has announced a private placement of common stock and warrants, aiming to raise approximately $5.6 million to support its ongoing clinical studies and general corporate purposes [1][2][3] Group 1: Offering Details - Aprea will sell a total of 6,288,857 shares of common stock (or pre-funded warrants) along with warrants to purchase an equal number of shares, at an effective offering price of $0.89 per share [1][2] - The warrants will have an exercise price of $0.765 per share, exercisable immediately upon issuance, and will expire two years from the effectiveness date of the registration statement [1][2] Group 2: Use of Proceeds - The gross proceeds from the offering are estimated to be around $5.6 million before deducting fees and expenses, which will be used for general corporate purposes and research and development expenses [2] Group 3: Clinical Development Focus - The financing is intended to support the ongoing ACESOT-1 dose-escalation study of APR-1051, a WEE1 kinase inhibitor, with the goal of optimizing dosage and patient population [3] - The addition of more patients to the study is expected to enhance the dataset for safety and early efficacy, potentially leading to significant clinical milestones [3] Group 4: Company Overview - Aprea Therapeutics is focused on developing innovative cancer treatments that target specific vulnerabilities in cancer cells while minimizing harm to healthy cells [6] - The company's lead programs include APR-1051 and ATRN-119, both of which are in clinical development for solid tumor indications [7]

We recently compiled a list of the 20 Most Profitable Stocks of the Last 20 Years. Regeneron Pharmaceuticals, Inc. is among the most profitable stocks. TheFly reported on January 22 that Evercore ISI increased its price target for REGN to $875 from $750 and maintained an Outperform rating on the stock. The firm expressed confidence in REGN’s updated outlook and recent pricing actions. Evercore ISI identified Dupixent and Eylea HD as key players in the company’s growth and noted that both products are well ...

NEW YORK, Jan. 29, 2026 (GLOBE NEWSWIRE) -- Applied Therapeutics, Inc. (Nasdaq: APLT) (the “Company” or “Applied”), a clinical-stage biopharmaceutical company dedicated to creating transformative treatments for rare diseases, today released the following letter to stockholders regarding the pending tender offer by AT2B, Inc. (“Purchaser”), an indirect wholly owned subsidiary of Cycle Group Holdings Limited (“Cycle”). January 29, 2026 Dear Applied Therapeutics Stockholders, As announced on December 11, 2025, ...

Media Release Entered into strategic collaboration with Dr. Reddy’s for commercialisation of eftilagimod alfa (efti) in all countries outside North America, Europe, Japan, and Greater ChinaIn January 2026, Immutep received ~A$30 million upfront payment from Dr. Reddy’s and is eligible to receive up to ~A$528 million in potential milestones, plus royalties on commercial sales of eftiStrong operational progress reported for TACTI-004 (KEYNOTE-F91) Phase III trial evaluating efti in first line non-small cell l ...

REDWOOD CITY, Calif., Jan. 29, 2026 (GLOBE NEWSWIRE) -- Soleno Therapeutics, Inc. (“Soleno”) (NASDAQ: SLNO), a biopharmaceutical company developing novel therapeutics for the treatment of rare diseases, today announced that it will participate in the following investor conferences in February and March: Guggenheim Emerging Outlook: Biotech Summit 2026Presentation Date: Thursday, February 12, 2026 at 11:30 AM ETPresentation Format: Fireside ChatWebcast: Here Oppenheimer 36th Annual Healthcare Life Sciences C ...

Expands clinical expertise to support disciplined advancement of the PSX-001 programMELBOURNE, Australia and NEW YORK, Jan. 29, 2026 (GLOBE NEWSWIRE) -- Incannex Healthcare Inc. (Nasdaq: IXHL), a clinical-stage biopharmaceutical company developing innovative combination therapies, today announced the appointment of three additional members to its recently established Clinical Advisory Board (“CAB”): Murray B. Stein, MD, MPH; Andrew Cutler, MD; and Amir Kalali, MD. The CAB was formed to provide independent c ...

TABLE OF CONTENTS As filed with the United States Securities and Exchange Commission on January 29, 2026. Registration Statement No. 333-292790 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 AgomAb Therapeutics NV (Exact name of registrant as specified in its charter) 2836 (Primary Standard Industrial Classification Code Number) N/A (I.R.S. Employer Identification Number) (State or Other Jurisdiction ...