Chongqing Genrix Biopharmaceutical (688443) 国泰君安·2024-09-01 07:41Investment Rating - The report maintains a "Buy" rating for the company with a target price of CNY 40.07, down from the previous target of CNY 54.07 [2][9] Core Views - The company's core product, IL-17 monoclonal antibody GR1501, has been approved for commercialization, targeting adult moderate-to-severe plaque psoriasis, with strong clinical trial results showing a 90.7% PASI 75 response rate at 12 weeks and a low 0.4% recurrence rate at 52 weeks [9] - The company has a rich pipeline of 15 products in development across autoimmune, oncology, and anti-infective fields, with several key clinical milestones expected in the near future [9] - The company's commercialization team is actively promoting market access and academic activities to drive product sales [9] Financial Performance - The company reported no revenue in H1 2024, with a net loss of CNY -362 million, slightly improved from the previous year due to reduced financial expenses and share-based payment costs [9] - The company's R&D investment in H1 2024 was CNY 286 million, with 439 R&D personnel, accounting for 65.13% of total employees [9] - The company's market capitalization is CNY 9,666 million, with a current share price of CNY 26.36 [5] Pipeline Progress - GR1501 (IL-17 monoclonal antibody): Approved for psoriasis in August 2024, with NDA submitted for axial spondyloarthritis in January 2024, expected approval in 2025 [9] - GR1802 (IL-4R monoclonal antibody): Phase III initiated for CRSwNP in August 2024, IND approved for allergic rhinitis in February 2024, and IND approved for pediatric atopic dermatitis in August 2024 [9] - GR1603 (IFANR1 monoclonal antibody): Completed Phase II enrollment for SLE in April 2024 [9] - GR1801 (rabies bispecific antibody): Entered Phase III in September 2023, expected to complete Phase III and submit NDA in H2 2024 [9] - GR2001 (tetanus monoclonal antibody): Phase III initiated in August 2024, with potential NDA submission in 2025 [9] - GR1803 (BCMAxCD3 bispecific antibody): Phase I data presented at EHA in May 2024, Phase II initiated in July 2024 [9] Valuation - The company's fair equity value is estimated at CNY 14.694 billion, with a target price of CNY 40.07 based on a DCF valuation model [12] - Key valuation assumptions include a risk-free rate of 2.17%, market return of 8.44%, beta of 1.80, and a perpetual growth rate of 3% [12][13]