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新药周观点:百济神州BTK抑制剂泽布替尼全球市场份额持续提升
国投证券·2025-03-02 10:25

Investment Rating - The report maintains an investment rating of "Outperform" with a rating of A [6] Core Insights - The global BTK inhibitor market is projected to reach 12.495billionin2024,reflectingayearonyeargrowthof16.2512.495 billion in 2024, reflecting a year-on-year growth of 16.25%, primarily driven by the increased market share of BeiGene's Brukinsa [21][22] - BeiGene's Brukinsa has achieved a market share of 21.2% in 2024, ranking third globally, and reached 24.9% in Q4 2024, surpassing AstraZeneca's Acalbrutinib [21][23] - Johnson & Johnson's Imbruvica remains the market leader with a share of 51.1%, while AstraZeneca's Acalbrutinib holds 25.0% [21][22] Weekly New Drug Market Review - From February 24 to March 2, 2025, the top five companies in the new drug sector by stock price increase were: Chuangsheng Group (65.17%), CanSino Biologics (33.64%), Fuhong Hanlin (28.87%), Kexing Pharmaceutical (24.69%), and Yongtai Biological (23.12%) [15][17] - The top five companies by stock price decrease were: WuXi AppTec (-20.33%), Hualing Pharmaceutical (-18.72%), Junsheng Tai (-14.81%), Yiming Oncology (-11.94%), and Ascentage Pharma (-9.41%) [15][17] Weekly New Drug Industry Analysis - The report updates the global BTK inhibitor market size and share based on the latest financial disclosures from companies like Johnson & Johnson, AbbVie, AstraZeneca, BeiGene, and Eli Lilly [21] - In Q4 2024, the global BTK inhibitor market size reached 3.329 billion, with a year-on-year growth of 5.16% [23][26] Weekly New Drug Approval & Acceptance - Three new drugs or new indications were approved for market entry in China this week, with 39 new drugs approved for IND, 33 new drugs accepted for IND, and 10 new drugs accepted for NDA [27][28] Domestic New Drug Industry Highlights - On February 25, 2025, Fosun Pharma's tenapanor, a sodium ion transport protein NHE3 inhibitor, received NMPA approval for controlling hyperphosphatemia in adult patients undergoing dialysis [35] - On February 24, 2025, CanSino Biologics announced a collaboration with Summit Therapeutics for the joint development of the PD-1/VEGF dual antibody injection for various solid tumors [35] - On February 25, 2025, Lino Pharmaceutical's SLN12140 injection for treating primary IgA nephropathy was approved for clinical trials [35]