医药生物行业定期报告：ADC领域新秀，映恩生物港股上市在即

Investment Rating - The report maintains a strong investment rating for the pharmaceutical and biotechnology sector, indicating it is expected to outperform the market [5]. Core Insights - The report highlights the upcoming IPO of Ying'en Biotech, a newcomer in the ADC field, with significant potential in its core pipeline products [2][20]. - The company has secured product authorizations with multiple partners, including BioNtech and GSK, with a total collaboration value exceeding $6 billion [3][23]. - The report emphasizes the importance of innovation in the pharmaceutical sector, particularly in the context of the ongoing tariff disputes, which are expected to have a limited impact on the industry [4][5]. Summary by Sections Market Review - The CITIC Pharmaceutical Index fell by 5.4% during the week of April 7-11, 2025, underperforming the CSI 300 Index by 2.5 percentage points [3]. - The pharmaceutical and biotechnology sector has seen a decline of 1.0% year-to-date, outperforming the CSI 300 Index by 3.7 percentage points [3]. Ying'en Biotech Overview - Ying'en Biotech's IPO process includes public offerings starting April 7, 2025, with shares expected to begin trading on April 15, 2025 [3][20]. - The company's core pipeline includes DB-1303 (HER2 ADC) and DB-1311 (B7-H3 ADC), with DB-1303 expected to submit for accelerated approval to the FDA in 2025 [3][20][26]. - DB-1311 is currently in Phase IIa trials, showing promising results in prostate cancer with an overall response rate (uORR) of 28.0% and a disease control rate (DCR) of 92.0% [3][4]. Product Pipeline and Collaborations - Ying'en Biotech has a robust pipeline with several ADC products in various clinical stages, including DB-1305 (TROP2 ADC) and DB-1310 (HER3 ADC) [4][20]. - The company has established collaborations with major pharmaceutical companies, which include significant milestone payments and revenue-sharing agreements [23][25]. - The report notes that the HER2 ADC market is competitive, but Ying'en Biotech's DB-1303 has a potential leading advantage in endometrial cancer indications [41][42]. Investment Strategy - The report suggests focusing on innovation as a key investment strategy, particularly in the context of the ongoing tariff disputes and the need for supply chain security [4][5]. - It recommends a diversified investment approach, including innovative biopharma and consumer healthcare sectors, to capitalize on domestic demand stimulation [4][5].