BeiGene-百济神州：一季度提前实现GAAPOP及净盈利-20250509

Investment Rating - The report maintains a "Buy" rating for the company, with target prices unchanged for US, Hong Kong, and A-shares [3][13]. Core Insights - The company achieved a total revenue of $1.12 billion in Q1 2025, representing a year-over-year increase of 48.6% and a slight quarter-over-quarter decrease of 0.9% [4]. - The company reported a GAAP net profit of$ 1.27 million in Q1 2025, a significant improvement from a net loss of $251 million in Q1 2024 and$ 152 million in Q4 2024 [4]. - The company generated $44.08 million in operating cash flow in Q1 2025, marking its first quarter of achieving both GAAP operating profit and net profit ahead of market expectations [4]. - The company maintains its full-year guidance for 2025, projecting total revenue between$ 4.9 billion and $5.3 billion, with a gross margin expected to be in the range of 80%-90% [4]. Revenue and Sales Performance - Zebutinib sales reached$ 792 million in Q1 2025, up 62.1% year-over-year, with US sales contributing $563 million, a 60.2% increase year-over-year [5]. - The company reported a significant increase in sales across regions, with European sales at$ 116 million (up 73.5% YoY) and Chinese sales at $81.1 million (up 41.3% YoY) [5]. Profitability and Cost Management - The product gross margin was 85.1%, showing a notable increase from 83.3% in Q1 2024, driven by the growth in Zebutinib sales and improved production efficiency [6]. - Operating expenses grew only 6% year-over-year, with R&D expenses increasing by 5% to$ 480 million, indicating strong cost control [6]. Financial Projections - The report projects total revenue for 2025 to be $5.03 billion, with a year-over-year growth rate of 32.1% [14]. - The company is expected to achieve a net profit of$ 115 million in 2025, with projections for 2026 and 2027 remaining stable [13][14]. Pipeline and R&D Progress - The company is focusing on key pipeline products, with upcoming data releases expected from various clinical trials in 2025 [12]. - Notable upcoming events include the ASCO conference where initial human data for B7H4 ADC and CDK2 inhibitors will be presented [12].