Zhao Yin Guo Ji·2025-07-04 03:27Industry Insights - The technology sector is significantly impacted by the recent US-Vietnam trade agreement, with Apple’s supply chain expected to benefit the most from the elimination of a major uncertainty [2][6] - The US will impose a 20% tariff on goods exported from Vietnam, while a 40% "transshipment" tariff will apply to goods from other countries, down from a previously announced 46% [2] - Companies with high revenue exposure to the US and production capabilities in Vietnam, such as AAC Technologies, BYD Electronics, and Hon Teng Precision, are likely to respond positively in the short term [6] Company Analysis - BeiGene (ONC US) has shown promising initial efficacy with its CDK4 inhibitor BGB-43395, which demonstrates good hematological safety and a lower incidence of neutropenia compared to other approved CDK4/6 inhibitors [6][9] - The incidence of grade 3 or higher treatment-related adverse events (TRAEs) was only 19.7% in the dose optimization cohort, significantly lower than the 29-55% range seen in other CDK4/6 inhibitors [6][9] - The objective response rate (ORR) for BGB-43395 in a small cohort of HR+/HER2- advanced breast cancer patients was 11%, with a disease control rate (DCR) of 55.6%, indicating potential for improved outcomes with longer follow-up [7][9] - The company plans to initiate a Phase III trial for BGB-43395 in second-line HR+/HER2- breast cancer in Q4 2025, maintaining confidence in its development [7][9] - The blood cancer treatment pipeline is competitive, with the BTK inhibitor Zebrutinib leading in new prescriptions and Sonrotoclax showing differentiated advantages over Venetoclax [8][9] - BeiGene is advancing clinical trials for Sonrotoclax in various indications and plans to submit new drug applications in China for R/R MCL and R/R CLL by 2H25 [8][9]