Investment Rating - The investment rating for the company is "Outperform the Market" (maintained) [1][6][24] Core Insights - The new generation ATTC platform is expected to address the toxicity and resistance issues associated with traditional ADCs, with potential for combination therapy with chemotherapy as a first-line standard treatment [2][3][23] - HMPL-A251 is the first candidate drug from the ATTC platform expected to enter clinical trials in Q4 2025, combining PI3K/PIKK inhibitors with HER2 antibodies [2][7][23] - The PAM pathway is identified as a promising target for broad tumor treatment, and the ATTC platform aims to expand the therapeutic window for targeted therapies [2][12][23] - The company's later pipeline is progressing smoothly, with clinical data for surufatinib in first-line PDAC expected to be presented at the ESMO Asia conference, and the SAFFRON study of savolitinib combined with osimertinib has completed patient enrollment [2][23] Summary by Sections ATTC Platform - The ATTC platform aims to overcome the toxicity and resistance challenges of traditional ADCs by targeting specific mutations, potentially reducing chemotherapy toxicity and enabling combination therapy [3][23] - HMPL-A251, the first clinical candidate from the ATTC platform, is designed to effectively inhibit the PAM pathway and has shown strong anti-tumor activity in HER2-positive models [7][8][12] Clinical Development - HMPL-A251 has received IND approval in the US, with the Chinese IND under review, and is expected to start Phase 1 clinical trials in Q4 2025 [8][12] - The clinical strategy includes enrolling HER2-positive or low-expressing patients and retrospective testing for PAM status [8][10] Future Pipeline - Besides HMPL-A251, two additional ATTC candidates (HMPL-A580 and HMPL-A830) are expected to enter global clinical stages in 2026 [12][23] - The PAM pathway is highlighted as a significant target due to its role in various cancers, with existing therapies showing limited clinical benefits due to associated toxicity [12][15]
和黄医药（00013）：新一代ATTC平台值得关注，首个候选药物预计25Q4进入临床