南方科技大学发表最新Science论文

Core Viewpoint - The research published by the team from Southern University of Science and Technology reveals a novel anti-phage immune strategy mediated by bacterial reverse transcriptase DRT9 and non-coding RNA, which synthesizes long poly-A-rich cDNA to defend against phage infection [2][4][5]. Group 1: Mechanism of DRT9 Immune System - DRT9 forms a hexameric complex with upstream non-coding RNA (ncRNA) to mediate anti-phage defense by inducing cell growth arrest during phage infection [4]. - During phage infection, the phage-encoded ribonucleotide reductase NrdAB complex increases intracellular dATP levels, activating DRT9 to synthesize long poly-A-rich single-stranded cDNA, which may capture essential single-stranded DNA binding proteins (SSB proteins) of the phage and inhibit its proliferation [4]. - The research team determined the cryo-electron microscopy structure of the DRT9-ncRNA hexameric complex, providing insights into its cDNA synthesis mechanism [4]. Group 2: Implications of the Findings - These findings highlight the diversity of reverse transcriptase-based antiviral defense mechanisms, expanding the understanding of the biological functions of reverse transcriptases [5]. - The research lays a theoretical foundation for developing novel biotechnological tools based on DRT9 [5].