上海交大/中科院深圳先进院合作最新Nature论文：为这一世界难题带来全新解决方案

Core Viewpoint - The article discusses the development of a genetically engineered strain of Vibrio natriegens, named VCOD-15, which effectively degrades complex organic pollutants in high-salinity environments, providing a novel solution for global environmental issues related to industrial wastewater and oil spills [1][2]. Group 1: Research Background - Industrial wastewater, petroleum pollution, and plastic pollution pose significant threats to marine biological safety due to their toxicity and persistence [1]. - The application of microorganisms in bioremediation is limited by the complexity of organic pollutants and the microorganisms' tolerance to salt stress [1]. Group 2: Research Development - The research team integrated five gene clusters into Vibrio natriegens to create the engineered strain VCOD-15, capable of degrading five organic pollutants: toluene, phenol, naphthalene, biphenyl, and dibenzofuran [2][4]. - The study utilized synthetic biology techniques, including natural transformation methods and iterative genome editing, to enhance the strain's capabilities [4][5]. Group 3: Performance and Application - VCOD-15 demonstrated over 60% removal rates for all five target pollutants within 48 hours, with a 100% degradation rate for biphenyl and nearly 90% for toluene and dibenzofuran [10]. - The strain maintained activity in high-salinity environments, thriving in wastewater with salinity levels of 102.5 g/L and 52.5 g/L, where control strains could not survive [10]. - In activated sludge reactors, VCOD-15 could completely remove high concentrations of pollutants within 12 hours, with residual levels below 2% after 48 hours [10]. - The strain also showed potential for soil remediation, achieving significant degradation of pollutants in saline soil within eight days [10].