Cell子刊：浙大团队临床试验证实，鱼油可改善糖尿病患者的睡眠

Core Viewpoint - The study highlights the potential of marine n-3 polyunsaturated fatty acids as a dietary intervention to improve sleep health in type 2 diabetes patients [12]. Group 1: Prevalence and Impact of Sleep Disorders - Approximately 537 million adults globally had diabetes in 2021, projected to rise to 783 million by 2045 [2]. - Sleep disorders are common among type 2 diabetes (T2D) patients, affecting 42%-76.8% of them, indicating a need for evidence-based strategies to improve sleep quality [2]. Group 2: Mechanisms of Sleep Regulation - Sleep regulation involves homeostatic pressure, wake-dependent regulation, and circadian rhythms, controlled by the central biological clock located in the suprachiasmatic nucleus (SCN) [5]. - The expression of clock genes in T2D patients is reduced, correlating with insulin resistance and elevated HbA1c levels, which may exacerbate sleep-wake disorders [6]. Group 3: Role of n-3 Polyunsaturated Fatty Acids - Dietary fat intake is closely linked to sleep and circadian rhythm balance, with a negative correlation observed between oily fish consumption and Pittsburgh Sleep Quality Index (PSQI) scores in the general population [6]. - Previous research confirmed that marine n-3 polyunsaturated fatty acids improve glucose and lipid metabolism in diabetic mice [7]. Group 4: Research Study and Findings - A 14-month randomized controlled trial (RCT) was conducted to assess the effects of fish oil supplements on sleep parameters and central biological clock improvement in T2D patients [8]. - The study found a significant association between regular fish oil intake and improved sleep quality among 27,549 T2D patients [9]. - Fish oil supplements were shown to enhance the expression of central clock genes, including Clock, Bmal1, and Per2, and restore rhythmic oscillation in key biological clock genes in hypothalamic neurons [9][10]. Group 5: Conclusion - The research underscores the potential of marine n-3 polyunsaturated fatty acids as a dietary intervention to enhance sleep health in type 2 diabetes patients [12].