华人学者本周发表5篇Cell论文：超越达尔文进化论；新型镇痛药；大脑中的恋爱开关；抑郁药抗肿瘤；让人类看见红外线的隐形眼镜

Group 1: New Pain Relief Drug - A new experimental pain relief drug, SBI-810, has been developed that provides effective pain relief for both acute and chronic pain, targeting the neurotensin receptor-1 (NTSR1) and activating specific pain signals while avoiding addiction-related side effects [3][6] - The research highlights the potential of NTSR1 biased allosteric modulators as a promising non-addictive pain management strategy, addressing both peripheral and central nervous system mechanisms [6] Group 2: Love Switch in the Brain - A study identified a specific group of neurons in the medial prefrontal cortex (mPFC) that regulates "romantic interest," integrating hormonal states and social cues to control social behaviors [8][11] - This research provides a theoretical basis and potential intervention targets for understanding gender-related social disorders, revealing a "love switch" in the brain that is dynamically regulated by hormonal changes [11] Group 3: Antidepressants Enhancing Cancer Immunotherapy - Research indicates that the serotonin transporter (SERT) acts as an immune checkpoint, and selective serotonin reuptake inhibitors (SSRIs) can significantly enhance T cell anti-tumor immunity, inhibiting tumor growth in various cancer models [13][17] - SSRIs, widely used for depression, show promise as candidates for cancer immunotherapy, potentially offering a more accessible treatment option compared to developing new cancer drugs [17] Group 4: Evidence for Acquired Inheritance Theory - A study provides direct evidence for the theory of acquired inheritance in rice, demonstrating that cold tolerance traits can be inherited through DNA methylation, challenging traditional Darwinian evolution frameworks [19][24] - The research reveals that environmental-induced epigenetic mutations can be stably inherited, offering new insights into adaptive evolution and innovative strategies for crop breeding [24] Group 5: Near-Infrared Vision Contact Lenses - A team developed wearable near-infrared (NIR) upconversion contact lenses that enable humans to perceive NIR spatial and color information, showcasing the potential of polymer materials in non-invasive visual enhancements [26][29] - This innovation could have broad applications in medical, information processing, and visual assistance technologies, potentially offering new solutions for visual impairments such as color blindness [29]