Core Viewpoint - The study published in Nature Aging highlights that endometrial aging negatively impacts female fertility, particularly in older patients, and identifies a new mechanism involving the loss of histone H3K27ac and progesterone receptor (PGR) function [2][4][6]. Summary by Sections - The research conducted by a team from Peking University Third Hospital analyzed clinical data from patients undergoing preimplantation genetic testing for aneuploidy (PGT-A) and confirmed that abnormal endometrial receptivity is a key factor in the reduced pregnancy rates among older patients [2][4]. - A comprehensive transcriptomic analysis of mid-secretory endometrium from younger (<35 years) and middle-aged (≥35 years) patients revealed that the loss of histone H3K27ac is associated with impaired endometrial receptivity in the middle-aged group [4]. - The study demonstrated that knocking out H3K27ac in endometrial stromal cells from younger women led to a decrease in the levels of the key endometrial receptivity regulator, PGR [4][6]. - The findings indicate that histone H3K27ac is a critical regulator of PGR and suggest that the loss of H3K27ac in the endometrium is linked to age-related declines in fertility [6].
Nature Aging：北医三院李蓉/潘恒/于洋团队揭示子宫内膜衰老新机制及其对生育能力的影响
生物世界·2025-05-24 07:50