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Core Viewpoint - Obesity is a health condition associated with excess fat accumulation, leading to various complications and comorbidities. GLP-1 receptor agonists have been developed and approved for obesity treatment, demonstrating effectiveness in appetite reduction and weight loss [1][2][4]. Summary by Sections Treatment Efficacy - GLP-1 receptor agonists, such as semaglutide and tirzepatide, have shown weight loss of 15%-20% after 68 to 72 weeks compared to placebo [2]. - A clinical trial indicated that participants lost an average of 10.6% of their body weight during 20 weeks of semaglutide treatment, with those continuing the drug losing an additional 7.9% over 48 weeks [5]. Challenges in Weight Maintenance - One of the biggest challenges in weight loss is maintaining the results, as many individuals experience weight regain after stopping treatment. Studies show that stopping GLP-1 receptor agonists can lead to significant weight gain [4][5]. - After one year of stopping semaglutide, approximately two-thirds of the weight lost can be regained [5]. Medication Management - It is recommended to continue GLP-1 receptor agonist treatment for at least 12 weeks to see significant effects, with a suggested continuation of 9 months to 1 year for consolidation [6]. - Users may experience increased satiety and reduced food intake initially, with weight loss typically ranging from 0.5 to 2 pounds per week [9]. Discontinuation Strategies - Gradual dose reduction is advised when stopping the medication to mitigate increased hunger, with specific recommendations for both non-diabetic and diabetic patients [10][12]. - Maintaining healthy eating habits and regular exercise is crucial post-discontinuation to prevent weight rebound [12]. Dietary and Lifestyle Recommendations - Key strategies to prevent weight regain include altering dietary habits by reducing high-calorie foods and increasing protein and fiber intake [13]. - Incorporating strength training and ensuring adequate sleep (7-9 hours per night) are also essential for maintaining weight loss and improving metabolic health [15].