减重减不动了？一文看懂使用司美格鲁肽时如何应对平台期

Core Viewpoint - The article discusses the phenomenon of weight loss plateau, explaining its causes and potential solutions, emphasizing the importance of continuous intervention for effective weight management [1][4][12]. Group 1: Causes of Weight Loss Plateau - Weight loss plateau occurs when the body adjusts to reduced calorie intake and increased energy expenditure, leading to a decrease in basal metabolic rate (BMR) after losing approximately 5 kg [4][6]. - The body's natural set point theory suggests that it maintains weight within a 10%-20% range around a predetermined set point, which can lead to weight regain after initial weight loss [6][12]. - The increase in appetite following weight loss can counteract the effects of weight loss interventions, such as medications or surgeries, rather than indicating a failure of these treatments [9][12]. Group 2: Effectiveness of Weight Loss Medications - New weight loss medications like Wegovy and Zepbound can double the time before reaching a weight loss plateau, extending the average plateau period from one year to two years [3][9]. - Clinical trials, such as the STEP 5 trial, show that participants using Wegovy can achieve significant weight loss, averaging 15.2% over two years, compared to placebo [11]. - Long-term use of GLP-1 receptor agonists is necessary for sustained weight management, as stopping the medication often leads to weight regain [12][11]. Group 3: Strategies to Overcome Weight Loss Plateau - To break through a plateau, it is essential to continue medication and focus on increasing basal metabolic rate through improved sleep quality, increased muscle mass, and dietary optimization [13][17]. - Lowering the body's set point is crucial, which may take six months to a year, requiring patience and commitment from individuals [15][18]. - Dietary changes, such as reducing high-calorie foods and increasing protein and fiber intake, can enhance metabolism and help overcome weight loss stagnation [15][17]. Group 4: Importance of Lifestyle Changes - Regular physical activity, including both aerobic and resistance training, is vital for maintaining weight loss and improving metabolic rate [17]. - Adequate sleep is essential for metabolic regulation, as sleep deprivation can lead to hormonal imbalances that increase appetite and reduce satiety [17]. - Individuals must adopt sustainable lifestyle changes to maintain weight loss, as temporary measures are unlikely to yield long-term results [18].