“头等大事”的新认知与新希望

Group 1 - The article emphasizes that androgenetic alopecia (AGA) is a significant health issue, with a prevalence rate of 21.3% in men and approximately 6.0% in women in China [3][4] - AGA is characterized by hair follicle miniaturization and hair cycle disruption, closely related to genetic factors and increased sensitivity to androgens such as dihydrotestosterone [3] - Clinical manifestations differ between genders: men typically experience a receding hairline (M-shaped) and thinning at the crown (O-shaped), while women show diffuse thinning at the crown with widening parting but usually retain their frontal hairline [4][6] Group 2 - The article suggests that maintaining a healthy lifestyle is crucial for managing AGA, including regular sleep patterns, balanced diet, and stress reduction, but emphasizes that lifestyle changes alone may not suffice [8][9] - The 2023 Chinese guidelines for AGA treatment highlight the importance of early diagnosis and intervention, stating that the earlier treatment begins, the better the outcomes [11] - Recommended treatments include oral medications such as 1mg finasteride for men and spironolactone or progestins for women, with minoxidil being the first-line topical treatment for both genders [11][12] - The introduction of the second-generation minoxidil foam in 2024 offers advantages over the first-generation solution, including a 2.85 times higher accumulation in hair follicles and reduced allergic reactions, enhancing patient compliance [11][12] - If there is no significant improvement after six months of medication, patients are advised to consider physical therapy or hair transplant surgery under medical guidance [11]