贾冰也瘦了？！自曝45天瘦了45斤，对外回复：真的就是少吃＋运动，你信吗？

Core Viewpoint - The article discusses the rising popularity of weight loss drugs such as Semaglutide and Tirzepatide, particularly following the significant weight loss of public figures like comedian Jia Bing and singer Chui Nalisah, highlighting the effectiveness and regulatory status of these medications in different markets [2][3][11]. Group 1: Celebrity Influence on Weight Loss Drugs - Comedian Jia Bing lost 45 pounds in 45 days, sparking interest in weight loss drugs like Semaglutide and Tirzepatide, which are approved for obesity treatment in the US and Europe but remain restricted for medical use in China [2][3]. - Singer Chui Nalisah also gained attention for losing 70 pounds, emphasizing that her weight loss was for health reasons rather than aesthetic ones, as she suffers from severe fatty liver disease [6][10]. Group 2: Efficacy of Semaglutide - Clinical trials (STEP series) show that Semaglutide can lead to an average weight loss of 15% in obese patients, significantly outperforming previous weight loss medications [23][28]. - In the STEP 1 trial, participants lost an average of 14.9%, with over one-third losing more than 20% of their body weight, while the placebo group lost only 2.4% [25]. - The STEP 4 trial indicated that continuous use of Semaglutide resulted in an 18.2% weight loss over time, demonstrating its long-term efficacy [26]. Group 3: Efficacy of Tirzepatide - The SURMOUNT-1 study showed that Tirzepatide led to significant weight loss in prediabetic patients, with average reductions of 22.5% at 72 weeks for the highest dosage group [29]. - In the SURMOUNT-2 study, patients with type 2 diabetes lost an average of 15.7% of their body weight, with a high percentage achieving over 5% weight loss [31]. - The SURMOUNT-5 trial revealed that Tirzepatide outperformed Semaglutide, with participants losing an average of 50.3 pounds compared to 33.1 pounds for those on Semaglutide [34].