替尔泊肽降糖这么猛，正常人使用为何不会低血糖？

Core Viewpoint - Tirzepatide is a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, effectively lowering blood sugar levels by mimicking the actions of GLP-1 and GIP [2][4] Mechanism of Action - Tirzepatide's glucose-lowering effect is glucose-dependent, promoting insulin release only when blood sugar levels are elevated, thus minimizing the risk of hypoglycemia in healthy individuals [4] - Traditional diabetes medications have limitations such as weight gain and hypoglycemia risk, leading to a focus on developing new drugs like tirzepatide and semaglutide, which show promising applications in type 2 diabetes treatment [5] - Clinical studies indicate that tirzepatide significantly improves insulin sensitivity and beta-cell function in type 2 diabetes patients, with an average reduction in HbA1c levels of 2.0%-2.5% [7] Clinical Efficacy - In head-to-head studies, tirzepatide demonstrated superior HbA1c reduction compared to semaglutide, with the SURPASS-2 trial showing a 2.46% reduction in the 15mg tirzepatide group versus a 1.86% reduction in the 1mg semaglutide group [7] - Tirzepatide also exhibits better control over fasting and postprandial blood glucose levels [7] Dual Target Benefits - The dual-target mechanism of tirzepatide enhances weight loss and glucose-lowering effects, with GIP playing a crucial role in insulin secretion, accounting for approximately 44% of insulin release after oral glucose intake [8][10] - GIP receptor agonists can restore insulin secretion in type 2 diabetes patients and may help reduce appetite, thereby aiding weight loss [11] Administration and Safety - Tirzepatide has a half-life of 5 days due to modifications, allowing for once-weekly administration, which improves patient adherence [10][11] - The safety profile of tirzepatide is favorable, with gastrointestinal side effects similar to other GLP-1 receptor agonists, indicating a high level of safety due to its mimicking of the body's natural weight regulation system [11]