Nature头条：华人学者利用类器官技术，让小鼠体内长出人类细胞

Core Viewpoint - The article discusses groundbreaking research by Professor Shen Xiling from MD Anderson Cancer Center, which successfully injected human organoids into the amniotic fluid of pregnant mice, resulting in the presence of human cells in the offspring's intestines, liver, and brain, indicating a potential breakthrough in the field of human-animal chimeras [1][10][12]. Group 1: Research Methodology - The research utilized a novel approach by injecting human cells in the form of organoids directly into the amniotic fluid of pregnant mice, allowing these cells to integrate into their respective organs during development [1][10]. - The study demonstrated that human organoid cells could proliferate and localize to specific organs, such as intestinal organoids in the intestines and liver organoids in the liver [12][14]. Group 2: Research Findings - Approximately 10% of the intestines of the newborn mice contained human cells, with human cells making up about 1% of the total intestinal cell population, while the proportions in the liver and brain were even lower [13]. - The human cells in the mice's organs appeared to function normally, as evidenced by the production of human serum albumin by the human liver cells, indicating their stability and functionality [14]. Group 3: Implications and Future Directions - The method of injecting human organoids into amniotic fluid is seen as a convenient and potentially revolutionary approach for creating human-animal chimeras, which could significantly advance research in organ transplantation [15]. - Ethical concerns have been raised regarding the introduction of human cells into animal brains, particularly regarding the potential for enhanced cognitive abilities; however, current findings show that the proportion of human cells in the mouse brain remains very low [16].