曹雪涛院士团队发表最新Nature Immunology论文

Core Viewpoint - The research highlights the role of MKRN2, an RNA-binding E3 ubiquitin ligase, in selectively inhibiting IL-6 translation, thereby restraining inflammation and autoimmune diseases [3][5][9]. Group 1: Mechanism of Action - MKRN2 binds to IL-6 mRNA and promotes K29 polyubiquitination of the translation initiation coactivator PAIP1 at lysine 179, which blocks PAIP1's interaction with the critical translation regulatory protein eIF4A, thus inhibiting IL-6 mRNA translation [6]. - The study indicates that E3-RBP's role in regulating specific pro-inflammatory cytokines remains unclear, necessitating further investigation [5]. Group 2: Clinical Implications - In clinical samples from patients with ulcerative colitis and rheumatoid arthritis, MKRN2 expression was found to be negatively correlated with IL-6 expression, suggesting its involvement in the progression of inflammatory diseases [8]. - The findings provide new insights into the mechanisms of inflammatory autoimmune diseases and suggest potential therapeutic strategies by interfering with the translation processes of specific pro-inflammatory cytokines [9].