海南大学发表最新Nature Immunology论文

Core Viewpoint - The research identifies a unique subset of liver portal macrophages (LPAM) that play a crucial role in maintaining liver immune homeostasis and have neuroprotective functions [3][6]. Group 1: Research Findings - The study published in Nature Immunology reveals the existence of a distinct LPAM network characterized by CX3CR1+ CD63+ cells, which differ significantly in transcription and spatial distribution from CX3CR1+ CD207+ liver capsule macrophages [5]. - LPAM survival is dependent on the colony-stimulating factor-1 receptor (CSF1R), and these cells are established in the liver portal area post-birth, supplemented by bone marrow-derived cells during liver homeostasis [5]. - During non-alcoholic steatohepatitis (NASH), the absence of LPAM leads to increased neutrophil infiltration and exacerbates sympathetic nerve degeneration [5]. Group 2: Implications for Liver Health - The findings suggest that the liver portal area is a critical region for regulating liver homeostasis and disease, with tissue macrophages capturing antigens, protecting sympathetic nerves, and limiting neutrophil recruitment during inflammation [7].