创新成果：L-哌啶甲酸的生物合成

Core Viewpoint - The fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on industrial ecological development and the transfer of scientific and technological achievements [1]. Group 1: Conference Overview - SynBioCon 2025 is organized by DT New Materials and supported by various academic and industrial organizations, aiming to facilitate over 1,000 connections between research institutions and startup projects [1]. - The conference will feature a special event showcasing 100 innovative achievements in synthetic biology manufacturing, promoting efficient technology transfer [1][10]. Group 2: Featured Project - The project "Biological Synthesis of L-Piperidine Carboxylic Acid" from Chongqing University focuses on producing L-PA, a crucial non-protein amino acid used in pharmaceuticals [6]. - The first-generation E. coli cell factory achieved a yield of approximately 52.68 g/L with a conversion rate of 90% and a productivity of 2.52 g/L-h, which is considered world-leading [6]. - The second-generation strain using yeast improved the yield to 75.54 g/L and has three core invention patents authorized [6][9]. Group 3: Technical Advantages - The engineered strain has over 90% stability and higher utilization of lysine due to pathway knockout and promoter optimization [8]. - The process benefits from shorter reaction times, lower temperatures to prevent contamination, and 100% optical purity of the product [8]. - The cost-effectiveness of the technology route contributes to high economic benefits [8]. Group 4: Intellectual Property and Collaboration - The project has three authorized core invention patents and offers collaboration opportunities through project partnerships, technology transfers, and joint laboratories [9]. Group 5: Conference Themes - The conference will explore the "1+4" theme, focusing on AI and bio-manufacturing, with applications in green chemicals, new materials, future food, future agriculture, and beauty raw materials [12]. - It aims to discuss the trends in bio-manufacturing during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [12]. Group 6: Service Platform - A global service platform for bio-based and bio-manufacturing industries is available at www.bio-basedlink.net [15].