2. 产业布局完善，形成区域联动优势 北京：研发创新策源地 天津：产业转化与制造基地 滨海新区规划建设"生物制造谷"，依托国家合成生物技术创新中心、合成生物学海河实验室，推动生物医药、绿色化学品等产业化 。 【SynBioCon】 自2023年发布 「中国合成生物学领域产业地图（2023年）」 共300+上榜企业名单（行业领取5000+份）以来，持续关注和服务产业 进展与创新，并将于2025年8月份发布 「中国生物制造产业地图（2025年）」 ， 即中国生物制造500+代表性企业榜单 。 我们将陆续发布各区上榜企业名单，并于 8月20-22日 在 浙江宁波 举办的 第四届合成生物与绿色生物制造大会 正式宣发 ，欢迎行业提前报名领取/上 榜。 京津冀地区作为国家战略发展的重要区域，在合成生物制造产业上的布局和政策支持具有显著的协同优势和战略意义。 同时， 三地已形成"研发（北京）—中试（天津）—产业化（河北）"的梯度布局，具备全球竞争力潜力。 1. 政策支持力度大，形成协同创新机制 武清区依托京津产业新城，吸引市场化基金和战略投资者，加速合成生物项目落地 。 河北：低成本化生产与配套 对此， 【SynBioCo ...

SynBioCon 2025 第四届合成生物与绿色生物制造大会 8月20-22日 浙 江 ·宁波东港喜来登酒店 8月20-22日 将于 浙江·宁波 举办 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2025 ) 。本届大会聚焦 "1+3"：AI+生物制造、绿色化工 与新材料、未来食品、未来农业四大方向 ，邀请行业领先企业、代表性产业化专家、政府、园区、资本、协会和联盟等各方共探"十五五"生物制造产业 发展趋势；AI赋能生物制造产业创新；哪些革新技术和产品将给生物制造产业带来持续的生命力；并致力于促进科技成果转移转化、产品规模化与人才挖 掘。 大会将同期举办 生物制造青年论坛 、 生物制造产业高层座谈会（第三期） 、 《2025人工智能赋能生物制造产业创新发展蓝皮书》闭门研讨会 、 合成 生物科技成果展示与对接 等活动 。 扫码参会报名 SynBioCon 2 025 8月20-22日，浙江·宁波 01 组织机构 主办单位 宁波德泰中研信息科技有限公司（DT新材料） 协办单位 北京大学宁波海洋药物研究院 宁波酶赛生物工程有限公司 支持单位 中国生物工程学会生物基材料专业委员会 浙江省合成生物 ...

/DT绿色化工交流群/ 让专业的人聚在一起, 生物基化学品/绿色生物制造等产业同行❤️↓ 生物基产业进展 | 华恒生物 【生物基能源与材料】 获悉，7月30日， 安徽华恒生物科技股份有限公司 （以下简称"华恒生物"）发布公告， 正在筹划发行境外股份（ H 股 ）并在 香港联合交易所有限公司上市事宜 。 华恒生物为深入推进公司全球化发展战略，提升品牌影响力与核心竞争力，巩固行业领先地位，充分借助国际资本市场的资源与机制优势，优化资本结 构，拓宽多元融资渠道，全面提升公司治理水平和综合实力，正在筹划发行境外股份（H股）并在香港联合交易所有限公司（以下简称"香港联交所"） 上市事宜（以下简称"本次H股上市"）。 公司正与相关中介机构就本次H股上市的具体推进工作进行商讨，相关细节尚未确定，本次H股上市不会导致公司控股股东和实际控制人发生变化。 华恒生物于2021年4月22日在上交所科创板上市 ， 目前市值约83.5亿元人民币。 作为合成生物学领域科创板企业，华恒生物赴港融资不仅可吸引国际资本，更能提升全球品牌认知度，为拓展海外市场奠定基础。 华恒生物是一家 以合成生物技术为核心 ， 专业从事 生物基产品 的研发、生产 ...

全球政策进展 | 工信部 【SynBioCon】 获 悉，7月 31日， 工业和信息化部消费品工业司正式公示了 "生物制造标志性产品名单（第一批）" ，共36项产品入选 。这一举措 标志着我国生物制造领域在技术创新和产业升级方面迈出了重要一步，也体现了国家对生物制造产业发展的高度重视和积极推动。 "生物制造标志性产品名单（第一批）"涉及到 36家企业，分别是： 首朗生物、微元合成、微构工场、合源生物、凯莱英、秦皇岛华恒生物、神舟生 物、金宇保灵生物、齐鲁制药、金赛药业、黑龙江新和成、凯赛生物、昌进生物、蓝晶微生物、轩凯生物、温州医科大学细胞生长因子药物和蛋白制剂 国家工程研究中心、海正药业、华恒生物、万泰沧海生物、富祥生物、华熙生物、润德生物、中科院青岛能源所、金丹乳酸、禾元生物、嘉必优、安琪 酵母、利尔生物、康方药业、汉和生物、庆智翔金泰生物、康弘药业、沃森生物、中国医学科学院医学生物学研究所、川宁生物、天康生物制药 。 生物制造标志性产品名单（第一批） ▼▼▼ | 序 름 | 产品名称 | | 申报单位 所属领域 所在地 | | 产品简介 | | --- | --- | --- | --- | --- | ...

SynBioCon 大会 | 美安康 顶尖国际新食品原料申报服务商 —— 美安康 将出席 2 025年8月20-22日 ， 浙江·宁波 举办 SynBioCon 2025 第四届合成生物与绿色生物制造大会 申报服务简介： 美安康国际法规部凭借深厚的行业积淀和顶尖的专家团队，专注于国际新食品原料的合规申报与安全性评估。我们精通美国 FDA 、欧盟 EFSA 等国际权威 监管机构的法规体系，为客户提供从原料评估、数据准备到申报策略制定的全流程专业服务。 我们的优势： （ 1 ）双语技术团队 具有专业的食品行业科学家，具备双语能力，在中国可以到客户现场进行指导，双语沟通，提高效率，协助你们高效申报，提出建设性建议。 （ 2 ）北美专家资源丰富 在美国有多位专家可供选择：不同的产品需要不同的申报专家，比如植物提取，生物发酵，合成生物学等。毒理专家团队具备多年成功申报 FDA GRAS 和 NDI 的经验。 （ 3 ）全链条服务能力 具有全链条服务的能力 ： Dossier 撰写 ， 可行性评估 ， GMP 体系建立 ， HACCP 体系建立 ， 毒理实验室合作经验 ， 毒理文章发表和撰写 ， FDA 问题回复和沟通 ...

Core Viewpoint - The article discusses the sustainable production of 1,4-butanediol (BDO) through engineered Escherichia coli, highlighting the potential for antibiotic-free fermentation methods and the optimization of metabolic pathways to enhance yield and efficiency [2][4][20]. Summary by Sections Introduction - 1,4-butanediol (BDO) is a significant non-natural chemical widely used in biodegradable plastics, with a substantial market potential. Traditional production relies on petrochemical methods, while biotechnological approaches face challenges such as low enzyme activity and high production costs [2][4]. Research Content - The study systematically optimized the E. coli chassis by integrating multiple copies of BDO synthesis genes, knocking out byproduct pathways, and engineering key enzymes to enhance metabolic flux. The introduction of a microaerobic fermentation strategy allowed for high BDO yields without antibiotics or inducers [4][5]. Metabolic Engineering Strategies - The research involved various strategies to improve BDO production, including: - Introducing external enzymes and optimizing gene expression to enhance BDO synthesis [7][11]. - Modifying the TCA cycle and enhancing ATP levels to redirect carbon flux towards BDO production [15][18]. - Utilizing the hok/sok system to maintain plasmid stability, achieving a low plasmid loss rate of 5.5% [18][19]. Production Results - In shake flask experiments, BDO production reached 7.88 g/L, the highest reported yield under similar conditions. In a 5-liter bioreactor, BDO production achieved 34.63 g/L with a glucose yield of 0.35 g/g and a production rate of 0.48 g/L/h [20][21]. Conclusion - The study demonstrates a comprehensive metabolic engineering approach for the sustainable industrial production of BDO from glucose, showcasing the potential for antibiotic-free processes and the need for further optimization to address byproduct accumulation [20][22].

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemistry, new materials, future food, and agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1][2]. Group 1: Conference Overview - The conference will take place from August 20-22, 2025, at the Sheraton Hotel in Ningbo, Zhejiang [1]. - It will feature various activities including a youth forum, high-level discussions, and a closed-door seminar on the "2025 AI Empowering Biomanufacturing Industry Innovation Development Blue Book" [1][2]. Group 2: Organizing Institutions - The event is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and supported by several academic and industry institutions, including Peking University Ningbo Institute of Ocean Medicine and Ningbo Enzyme Science Biotechnology Co., Ltd. [2]. Group 3: Agenda Highlights - Day 1 will include registration, a high-level discussion on biomanufacturing, and a youth forum focused on innovation [5][9]. - Day 2 will feature an opening ceremony, macro forums on biomanufacturing, and specialized discussions on green chemistry and new materials [6][12]. - Day 3 will focus on AI applications in biomanufacturing and future food and agriculture discussions [27][30]. Group 4: Key Publications - The conference will announce the "China Synthetic Biology Industry Distribution Map (2025 Edition)" which includes a list of over 500 representative companies in the biomanufacturing sector [33].

Core Viewpoint - The article discusses the development of humanized "4D" collagen protein based on natural collagen, aiming to address the immunogenicity and pathogenic risks associated with traditional animal-derived collagen [1]. Group 1: Research and Development - The research team led by Professor Li Shuang from South China University of Technology focuses on biomimetic "honeycomb" porous structures for molecular construction, optimizing collagen triple helix sequences through gene editing [1]. - The team combines computer simulation design with cross-scale self-assembly templates to achieve a synergistic optimization of high specific surface area, strong mechanical strength, and biological activity [1]. - Techniques such as transmission electron microscopy are utilized to analyze the hierarchical structure, and in vitro cell experiments validate the biocompatibility and regenerative efficacy of the developed materials [1]. Group 2: Industry Applications - The innovative collagen material is expected to provide new biological materials for regenerative medicine, promoting upgrades in industries such as medical aesthetics and bone repair [1]. - Professor Li Shuang will present a talk titled "Molecular Design of Humanized '4D' Collagen Protein" at the SynBioCon 2025 conference, which focuses on synthetic biology and green biological manufacturing [1][14]. Group 3: Conference Details - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biological manufacturing, as well as advancements in green chemistry, new materials, future food, and agriculture [14]. - The conference will feature various activities, including a youth forum on biological manufacturing, high-level discussions on the industry, and a closed-door seminar on the "2025 Artificial Intelligence Empowering Biological Manufacturing Industry Innovation Development Blue Book" [14][15].

Core Insights - The establishment of the first synthetic biology innovation center in Northwest China at Haesfu marks a significant milestone in the field of technological innovation, enhancing the company's capabilities in synthetic biology technology commercialization [1][3] - Haesfu is recognized as an established leader in the biological manufacturing sector, focusing on the development of next-generation natural active ingredients [3][5] Summary by Sections Synthetic Biology Innovation Center - Haesfu has inaugurated a new research and development center spanning over 2,000 square meters, alongside the Shaanxi Provincial Synthetic Biology Innovation Center, indicating a robust commitment to advancing synthetic biology technology [1] Technological Advantages - The company holds numerous core patents related to synthetic biology, covering the entire chain from gene screening to efficient expression and precision fermentation [5] - Haesfu has assembled a top-tier research team led by PhD graduates from renowned universities, with an average research experience exceeding 10 years [5] - The company has developed a unique "laboratory-pilot-1000-ton factory" conversion platform, significantly shortening the product development cycle [5] Sustainability and Product Focus - Haesfu is pioneering low-carbon and energy-saving fermentation processes, aiming for 100% renewable raw materials to achieve a sustainable future [5] - The company is concentrating on high-value natural products, such as rare natural pigments, natural flavors, and new antioxidants, to build a globally competitive product portfolio [5] Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biological manufacturing, as well as advancements in green chemistry, new materials, future food, and agriculture [4][6] - The conference will feature various activities, including a youth forum, high-level discussions, and a closed-door seminar on the "2025 Blue Book for AI Empowering Biological Manufacturing Industry Innovation Development" [4][6]

Core Viewpoint - The SynBioCon 2025 conference will focus on the integration of AI with biomanufacturing, green chemicals and new materials, future food, and future agriculture, aiming to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan period [1]. Group 1: Conference Overview - The conference will be held from August 20-22, 2025, in Ningbo, Zhejiang [1]. - It aims to promote the transfer and transformation of scientific and technological achievements, product scaling, and talent acquisition in the biomanufacturing sector [1]. Group 2: Organizers and Support Units - Organized by Ningbo Detaizhongyan Information Technology Co., Ltd. (DT New Materials) and co-organized by several academic and research institutions [2]. - Supported by various associations and alliances, including the Chinese Society of Biotechnology and the Zhejiang Synthetic Biology Industry Technology Alliance [2]. Group 3: Expert Guests - Notable experts include Zhang Xian'en, Dean of the School of Synthetic Biology at Shenzhen University, and other prominent figures from various universities and research institutes [4][5][6][7][10][12][14][18][20][22][30][32]. - The conference will feature presentations on topics such as the construction of efficient cell factories for aromatic compounds and the biomanufacturing of polyamide materials [8][11][23][31]. Group 4: Conference Agenda - The agenda includes a series of forums and discussions on topics like green chemicals, AI in biomanufacturing, and future food and agriculture [36][37]. - Activities will include a high-level roundtable on biomanufacturing and a youth forum to showcase innovative achievements in the field [36].