新研究揭示肥胖隐藏诱因：为何"少吃多动"效果有限？

Core Viewpoint - Obesity is recognized as one of the most severe global public health crises of the 21st century, with the World Health Organization reporting that the number of overweight individuals has nearly tripled in the past fifty years, and this trend continues to rise [3][4] Group 1: Traditional Views and New Insights - The traditional view of obesity as a simple energy imbalance (overconsumption vs. insufficient expenditure) has dominated obesity prevention strategies for decades [3] - Recent research by Professor Barbara E. Corkey reveals that the causes of obesity are more complex, involving food additives and environmental endocrine disruptors that may alter metabolic regulation mechanisms [3][4] Group 2: Metabolic Disruptors - The concept of "obesogens," or obesity-inducing substances, has emerged as a critical factor in understanding obesity, as these chemicals interfere with metabolic regulation rather than merely increasing caloric intake [6][8] - These obesogens are found in food packaging, household products, and even air pollutants, entering the body through various pathways and potentially leading to fat accumulation despite healthy eating and exercise [8][9] Group 3: Sources and Impact of Obesogens - Obesogens are present in modern agriculture (fertilizers and pesticides), food packaging (plasticizers), household items (flame retardants), and cosmetics, complicating the traditional "eat less, move more" strategy [9] - Long-term exposure to these chemicals can disrupt metabolic balance, leading to persistent fat accumulation even in individuals who maintain a healthy lifestyle [8][9] Group 4: Paradigm Shift in Obesity Research - The obesity research field is undergoing a fundamental shift, moving focus from individual behavior to the broader environmental health context, as highlighted by Corkey's obesogen theory [10] - This new paradigm emphasizes the need for a systematic research framework to identify potential obesogens, understand their molecular mechanisms, and develop exposure-blocking strategies [10][11] Group 5: Comprehensive Strategies for Obesity Prevention - A multi-faceted approach is necessary to combat the global obesity epidemic, combining personal health management with societal environmental changes [12] - The integration of micro-level behavior interventions with macro-level environmental governance is essential for creating a healthier future and reshaping societal health ecosystems [12]