华南理工魏东教授组：微藻高光强化CO₂高效定向转化为脂质最新研究进展

Core Viewpoint - The article discusses the innovative strategies for enhancing CO2-to-lipid bioconversion in microalgae, specifically focusing on the oleaginous Coccomyxa subellipsoidea, to address the challenges of biomass and lipid accumulation for sustainable biodiesel production [1][2]. Summary by Sections Research Findings - The study achieved a biomass concentration of 10.00 g/L, a carbon fixation rate of 1.42 g/L/d, a lipid content of 51.84% dry weight, and a lipid yield of 401.75 mg/L/d under high light intensity (300 μmol/m²/s) [2]. - Chlorophyll fluorescence analysis indicated that high light intensity initially suppressed photosynthetic activity but later activated non-photochemical quenching (NPQ), enhancing the algae's high light tolerance [4]. - Metabolomics analysis showed that high light conditions upregulated protein and free amino acid degradation, facilitating the recycling of nitrogen and carbon resources, which maintained basic cellular metabolism and directed carbon flow towards acetyl-CoA for lipid synthesis [5]. Implications for Biofuel Production - The fatty acid methyl esters produced from this algal strain meet the biodiesel reference standards of China, the USA, and the EU, providing a significant theoretical basis and application case for the development of carbon neutrality and biofuel production technologies [6].