清华大学发表最新Nature论文

Core Viewpoint - The research led by Tsinghua University focuses on a novel strategy for enhancing plant immunity against pathogens, addressing the growing threats to global food security and environmental sustainability posed by plant diseases [1][4]. Group 1: Research Innovation - The study introduces a simple and efficient method for designing artificial plant disease resistance genes by utilizing protein engineering [1]. - A fusion protein is expressed in plants, combining a pathogen protease recognition cleavage site (PCS) with an active plant NLR immune receptor (aNLR) [4]. - The aNLR remains inactive until cleaved by the pathogen's protease, which triggers a strong immune response in the plant [4]. Group 2: Experimental Validation - The engineered NLR receptor has been shown to confer broad-spectrum and complete resistance to various potyviruses in model plants like Nicotiana benthamiana and economically important crops such as soybeans [6]. - This approach demonstrates the potential for a single engineered receptor to provide extensive protection against multiple viral threats [6]. Group 3: Broader Implications - The strategy is promising for developing universal plant disease resistance, as various pathogens across different kingdoms encode proteases [7]. - This could lead to enhanced resistance against a wide range of pathogens, including viruses, bacteria, fungi, and nematodes [7].