绕过抗生素耐药性！浙江大学王本/徐峰团队提出对抗超级细菌新方法

Core Viewpoint - The article discusses a groundbreaking alternative therapy for treating methicillin-resistant Staphylococcus aureus (MRSA) infections, which poses a significant threat due to its antibiotic resistance and high mortality rates globally [1][2][4]. Group 1: Research Findings - A study published in Nature Biotechnology introduces a novel method using antibody-polysialic acid conjugates (APC) to encapsulate MRSA in a calcium shell, effectively neutralizing its activity while enhancing the host's immune response [3][4][6]. - The research demonstrates that systemic administration of APC can efficiently and safely treat chronic lung infections and chronic osteomyelitis caused by MRSA in mouse models [8][10]. - The mechanism involves attracting calcium ions to the bacterial cell wall, leading to calcification that disrupts MRSA's energy metabolism and essential metabolic pathways, resulting in bacterial death [6][8]. Group 2: Implications and Future Applications - This innovative approach not only targets MRSA but may also be applicable to other antibiotic-resistant infections due to the critical role of cell wall teichoic acids in Gram-positive bacteria [10]. - The study highlights the potential for APC to stimulate immune responses, increasing the expression of calprotectin and S100A8/S100A9 in macrophages, thereby promoting bacterial clearance [8].