想大吃大喝，可以暂停使用司美格鲁肽等减重药物吗？

Core Viewpoint - The article discusses the implications of pausing the use of semaglutide and provides guidance on how to do so safely while maintaining weight management and health benefits [2]. Summary by Sections Timeline: What Happens After Injecting Semaglutide - 1-2 hours: The drug begins to be absorbed into the bloodstream after subcutaneous injection [6]. - 24-48 hours: Peak concentration in the blood is reached, actively binding to GLP-1 receptors [7]. - 1-2 weeks: Initial noticeable effects such as reduced appetite and improved blood sugar regulation may begin [8]. - 4-5 weeks: Steady state levels are achieved, leading to more pronounced appetite suppression and accelerated weight loss [9]. Best Way to Pause Medication - It is recommended to start with the lowest dose and gradually increase it over months to minimize potential side effects. Sudden discontinuation does not typically cause withdrawal symptoms [10]. - Gradually reducing the dose is advised to mitigate increased hunger that may occur after stopping the medication [12]. - Adjusting injection intervals can help manage the pause: minimum 2 days between injections or less than 12 days for extending the cycle [12]. Effects After Stopping Medication - A 2021 clinical trial showed that participants lost an average of 10.6% of their weight during treatment, but those switched to a placebo regained an average of 6.9% of their weight, while those continuing semaglutide lost an additional 7.9% [13]. - An observational study indicated that 18% of patients regained their lost weight after one year off the medication, with 26% regaining over 25% of their lost weight [13]. Importance of Continuing Medication - The STEP 5 trial demonstrated that continuous use of semaglutide for 2 years resulted in a weight loss of 15.2% compared to placebo, with 77.1% of patients losing at least 5% of their weight [16]. - The SELECT trial showed that patients maintained an average weight loss of about 10% over 4 years, emphasizing the chronic nature of obesity and the need for long-term management [16]. Obesity as a Chronic Disease - Recent studies confirm obesity as a chronic disease, with 76.8% of patients and 94.6% of doctors agreeing on its classification [17]. - Obesity leads to various health issues, increasing the risk of type 2 diabetes and cardiovascular diseases, necessitating its inclusion in chronic disease management [17]. Weight Loss and Chronic Complications - Weight loss of 5% can improve hypertension and blood sugar levels, while a 10-15% reduction significantly lowers risks associated with cardiovascular diseases and diabetes [19]. - Overall, weight loss interventions can substantially reduce the risk of chronic complications and improve health outcomes for obese patients [19].