天工所李德茂等：改造裂殖壶菌同时生产DHA和虾青素

Core Viewpoint - Astaxanthin, a highly effective antioxidant pigment, is gaining attention for its applications in food, cosmetics, and pharmaceuticals, with a recent study demonstrating a high-yield production system using Schizochytrium for both astaxanthin and DHA [1][3]. Group 1: Research Findings - The study reported an increase in astaxanthin content from 7.56 μg/g to 55.17 μg/g through electroporation-induced color screening [2]. - Further enhancement of astaxanthin content to 374.85 μg/g was achieved by overexpressing five key genes involved in the astaxanthin synthesis pathway [2]. - The final engineered strain produced astaxanthin at a yield of 29.53 mg/L (1.913 mg/g DCW) while maintaining DHA production at 3.83 g/L, constituting 45% of total lipid content [2]. Group 2: Implications for Industry - The reported astaxanthin yield represents the highest level achieved in Schizochytrium to date, laying a foundation for the commercial scalability of astaxanthin biosynthesis [3]. - The advancements in metabolic engineering and mutagenesis techniques highlight the potential for increased production efficiency in the biotechnology sector [1][3]. Group 3: Upcoming Events - The 4th Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, focusing on AI and bio-manufacturing, green chemistry, new materials, future food, and agriculture [6][8]. - The conference will feature various activities, including a youth forum, high-level discussions, and a closed-door seminar on AI-enabled innovations in bio-manufacturing [6][7].