Cell：刘尊鹏/张珊珊等揭示阿尔茨海默病进展与否，关键或在表观基因组稳态

Core Viewpoint - The study highlights the importance of understanding the epigenomic mechanisms underlying Alzheimer's disease (AD) progression and cognitive resilience, suggesting potential new intervention strategies to delay cognitive decline [3][10]. Group 1: Research Overview - The research published in the journal Cell explores the epigenomic rewiring in Alzheimer's disease progression and cognitive resilience, utilizing single-cell multi-region epigenomic and transcriptomic techniques [4][10]. - A total of 111 individuals were selected for the study, including 57 non-AD, 33 early-stage AD, and 21 late-stage AD patients, covering six brain regions [7]. Group 2: Key Findings - The study identified over 1 million cis-regulatory elements and defined 123 functional modules, revealing cell-type specific associations with genetic risk factors for Alzheimer's disease and other brain disorders [7][8]. - It was found that there is a widespread phenomenon of "epigenomic information loss" in the brains of Alzheimer's patients, correlating with the functional decline of neurons and glial cells [8]. Group 3: Cognitive Resilience Insights - The research elucidated the epigenomic basis of cognitive resilience, showing that individuals with stronger cognitive resilience maintain higher levels of epigenomic information in key cell types [9]. - The study suggests that the stability of the epigenome is a critical molecular mechanism supporting cognitive resilience, providing new avenues for enhancing cognitive function and delaying Alzheimer's disease progression [9][10].