清华大学×北京大学合作发表最新Cell论文

Core Viewpoint - The research highlights the role of bivalent chromatin in regulating cell fate through composite transposons, specifically focusing on the SVA transposon and its implications in hematopoiesis and aging [3][6]. Group 1: Research Findings - The study reveals that composite transposons carry bivalent histone marks, with activating and inhibiting marks located in different regions [6][9]. - A genome-wide CRISPR-Cas9 screening identified multiple genes that control bivalent chromatin at the SVA locus [9]. - Different subsets of SVA are activated to enhance the expression of various genes during myeloid hematopoiesis [9]. Group 2: Mechanisms and Implications - The SVA transposon exhibits RNA-dependent cis-regulatory functions that promote hematopoietic aging [9]. - The presence of H3K9me3 at the 5' end and H3K27ac at the 3' end of SVA is crucial for its transcriptional regulation [6][9]. - Activation of certain bivalent SVA elements is essential for the expression of multiple erythroid genes, while their inhibition leads to insufficient erythropoiesis [6].