创新成果：生物基材料单体与材料生物制造平台

Core Viewpoint - The SynBioCon 2025 conference aims to facilitate the transformation of scientific achievements into industrial applications, focusing on synthetic biology and green manufacturing [2][17]. Group 1: Conference Overview - The fourth Synthetic Biology and Green Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang [2][17]. - The event is organized by DT New Materials and supported by various academic and industrial organizations, emphasizing the development of industry ecosystems and technology transfer [2][17]. - The conference will feature over 100 innovative synthetic biology manufacturing achievements, promoting efficient technology transfer within the industry [2]. Group 2: Featured Projects - A project from Chongqing University focuses on a bio-manufacturing platform for bio-based materials, addressing the shortage of key monomers like hexamethylenediamine, succinic acid, and butanediol in China [7][8]. - The project utilizes advanced metabolic engineering to create a bacterial cell factory capable of producing 1,4-succinic acid with a yield of approximately 145.9 g/L and a sugar-to-acid conversion rate of 0.97 g/g, showcasing world-leading production efficiency [8][9]. Group 3: Technical Advantages - The 1,4-succinic acid production process benefits from optimized bacterial strains, shorter reaction times, lower temperatures, and cost-effective technical routes, leading to higher yields and lower costs [9]. - The 1,4-butanediol production process leverages Pichia pastoris, which is genetically stable and efficient in expressing foreign proteins, with a cost-effective acidic fermentation process [10]. Group 4: Intellectual Property and Collaboration - The project holds patents for the recombinant plasmids and engineered strains used in the production of succinic acid and hexamethylenediamine, indicating a strong intellectual property position [11]. - Collaboration with companies such as Yantai Wanhua Chemical and Guangdong Kingfa Technology is established, inviting further partnerships for technology transfer [13].