Nature Neuroscience：宋洪军/明国莉/周毅团队揭示人类海马新生未成熟神经元的独特演化规律

Core Viewpoint - The study published in Nature Neuroscience reveals significant differences in the expression patterns of immature dentate granule cells (imGC) across various mammalian species, while highlighting the conserved biological processes involved in neurogenesis [3][4][7]. Group 1: Research Findings - The research systematically maps the cross-species molecular profiles of hippocampal neurogenesis, showing extensive differences in transcriptional expression among mammals, yet a high degree of conservation in biological processes [4][7]. - A specific subclass of ATPase enriched in human hippocampal imGC was identified, emphasizing its necessity in the development of human neurons [4][7]. - The study utilized machine learning-assisted analysis of published single-nucleus RNA sequencing datasets to identify imGC characteristics at the transcriptomic level in the hippocampus of macaques [7]. Group 2: Comparative Analysis - Cross-species comparisons (humans, macaques, pigs, and mice) revealed that, aside from a few shared genes (e.g., DPYSL5), imGC predominantly exhibits species-specific gene expression, converging on common biological pathways regulating neuronal development [7]. - The research highlights the importance of conducting independent molecular and functional analyses of adult neurogenesis across different species due to the observed gene expression heterogeneity and biological process convergence [7].