体重骤降，糖友重获新生！《柳叶刀》爆料震撼Meta分析：减重幅度与2型糖尿病缓解率成正比

Core Insights - A groundbreaking meta-analysis published in The Lancet Diabetes & Endocrinology reveals a strong dose-response relationship between weight loss and diabetes remission in overweight or obese patients with type 2 diabetes [6][9] Group 1: Weight Loss and Diabetes Remission - The study analyzed 22 high-quality randomized controlled trials, focusing on complete and partial remission indicators [7] - Complete remission is defined as HbA1c below 6.0% or fasting blood glucose below 5.6mmol/L without any antidiabetic medications after one year of intervention [7] - Dramatic differences in complete remission rates were observed based on weight loss: only 0.7% of patients losing less than 10% of their weight achieved complete remission, while nearly half (49.6%) of those losing 20%-29% did, and an impressive 79.1% of those losing over 30% achieved complete remission [7][8] Group 2: Partial Remission Rates - Partial remission rates also showed a clear stepwise increase: 5.4% for less than 10% weight loss, 48.4% for 10%-19%, 69.3% for 20%-29%, and 89.5% for over 30% weight loss [7] - Each 1% weight loss increases the probability of complete remission by 2.17% and partial remission by 2.74% [8] Group 3: Implications for Clinical Practice - The findings strongly support that weight loss is a critical factor in managing type 2 diabetes and reducing the risk of related complications, providing clear treatment goals and expected outcomes for clinicians and patients [9]