Core Viewpoint - Lack of physical activity poses a significant threat to public health, increasing the incidence and mortality rates of non-communicable diseases (NCDs) globally. Exercise is recognized as the most effective and cost-efficient intervention to promote overall health and reduce the burden of NCDs. However, recent estimates indicate that 1.4 billion adults (27.5% of the global adult population) fail to meet recommended physical activity levels, with a concerning 81% of children and adolescents aged 11-17 also not meeting these levels [3][4]. Group 1 - Early-life exercise has been shown to extend healthspan but not lifespan in mice, with significant long-term health benefits observed from just three months of exercise during early life [4][6]. - The study highlights that early physical activity correlates positively with enhanced aerobic fitness, increased bone mineral density (BMD), and reduced risks of obesity, hypertension, type 2 diabetes, and heart disease in adulthood [6][7]. - The research indicates that early-life exercise leads to improved overall health in aging mice, enhancing metabolic function, cardiovascular health, and muscle strength while reducing inflammation and frailty [7][9]. Group 2 - The findings emphasize the importance of early-life physical activity interventions to optimize long-term health outcomes, suggesting that enhanced fatty acid metabolism in skeletal muscle may be a key mechanism behind these health benefits [9][10]. - Future research is necessary to explore the mechanisms by which early-life exercise impacts long-term health and to apply these findings to human populations [9].
运动要趁早!我国学者Nature子刊论文证实,生命早期的运动可延缓衰老、延长健康寿命
生物世界·2025-08-20 00:00