Nature子刊：武汉大学普颖颖团队等揭示细菌新型细胞器保护mRNA的机制

Core Viewpoint - The research reveals that aggresomes, a type of non-membrane organelle in Escherichia coli, play a crucial role in protecting mRNA integrity under stress, thereby enhancing bacterial survival and recovery efficiency in adverse conditions [4][7][9]. Group 1: Research Findings - The study published in Nature Microbiology demonstrates that aggresomes selectively protect mRNA through electrostatic repulsion mechanisms, which is vital for the survival of persister cells under stress [4][8]. - Long-term stress leads to ATP depletion, resulting in increased formation and accumulation of aggresomes, along with specific mRNA enrichment within these structures [8]. - The research indicates that mRNA stored in aggresomes facilitates rapid reactivation of translation, contributing to a reduction in lag phase during bacterial growth after stress removal [8][9]. Group 2: Implications - Understanding the role of aggresomes in mRNA protection provides insights into bacterial resistance mechanisms, potentially guiding the development of novel antibacterial strategies targeting persister cells [4][7]. - The findings highlight the significance of non-membrane organelles in bacterial stress responses, which could influence future research in microbiology and antibiotic resistance [4][9].