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因涉嫌性骚扰被开除,mTOR研究先驱远走捷克从新建立实验室,如今再发Nature
生物世界·2025-08-21 08:00

Core Viewpoint - The article discusses the career trajectory of David Sabatini, highlighting his significant contributions to mTOR research and the subsequent controversies that led to his professional downfall and relocation to the Czech Academy of Sciences for continued research [3][4][5]. Group 1: David Sabatini's Career Achievements - David Sabatini, born in 1968, is renowned for his discovery of the mTOR protein and its role as a direct target of rapamycin [3]. - He published over 200 papers, with more than 70 in top journals like Cell, Nature, and Science, accumulating over 190,000 citations and an H-index of 160 [3]. Group 2: Controversy and Professional Downfall - In October 2020, Sabatini faced allegations of sexual harassment from a female researcher, leading to his resignation from the Whitehead Institute in August 2021 and termination from HHMI [4]. - He filed a lawsuit claiming he was a victim of false accusations, which he argued destroyed his professional and personal reputation [4]. Group 3: Current Research and Future Directions - After unsuccessful attempts to secure a position at New York University due to protests, Sabatini accepted a position at the Czech Academy of Sciences in November 2023 [5]. - His team published a significant paper in Nature in August 2025, detailing the structural basis for the dynamic regulation of mTORC1 by amino acids [5]. - The research revealed the complex interactions within the mTORC1 signaling pathway, emphasizing the role of amino acid sensors and their structural dynamics [7][9][10][12].