南方科技大学发表最新Cell论文

Core Viewpoint - The study reveals that the oligomerization of Shank3 regulates the material properties of postsynaptic density (PSD) condensates, which are crucial for synaptic plasticity and neuronal functions related to learning and memory [3][5][7]. Summary by Sections - The research team from Southern University of Science and Technology published findings indicating that PSD condensates exhibit soft-glass-like properties, with Shank3 protein oligomerization playing a key role in governing these material characteristics [3][5]. - The study found that the reconstructed PSD condensates formed a soft-glass material without signs of irreversible amyloid-like structures. This glass-like formation relies on specific, multivalent interactions among scaffold proteins, which mediate the network flow of PSD proteins [4]. - Disruption of Shank3's SAM domain-mediated oligomerization, observed in patients with Phelan-McDermid syndrome, leads to a softening of PSD condensates, impairing synaptic transmission and plasticity, and resulting in autism-like behaviors in mice [4][5]. - Overall, the research emphasizes the importance of the material properties of PSD condensates in neuronal synaptic functions related to learning and memory [7].