使用司美格鲁肽减重时，如何精准影响身体成分积极变化？

Core Viewpoint - GLP-1 receptor agonists, such as semaglutide, not only alter external appearance but also significantly impact body composition, which is crucial for understanding overall health effects beyond standard weight loss metrics [2][6]. Group 1: Impact on Body Composition - The study analyzed 241 patients using abdominal CT scans before and after five years of semaglutide treatment, employing an automated AI tool to quantify various body composition metrics [6]. - In the weight loss group, reductions were observed in visceral fat area (VAT), subcutaneous fat area (SAT), muscle area, and liver volume, with an increase in liver density [6]. - Conversely, in the weight gain group, increases in VAT, SAT, and intermuscular adipose tissue (IMAT) area were noted, along with a decrease in muscle density [6]. Group 2: Importance of Body Composition Metrics - Traditional clinical assessments like weight, waist circumference, and BMI do not capture the significant tissue-specific changes that CT can evaluate, which are important for assessing risks related to cardiovascular metabolic diseases, frailty, and mortality [4][7]. - The findings suggest that body composition changes provide a more comprehensive understanding of the effects of GLP-1 agonists on health [6].