Nature子刊：刘燕/王存玉/罗聃团队开发新型纳米药物，缓解细胞衰老，逆转衰老相关疾病

Core Viewpoint - The article discusses the development of a nanomedicine (EM-eNM) that engages energy metabolism to maintain mitochondrial homeostasis, alleviate cellular aging, and reverse age-related diseases [4][10]. Group 1: Research Background - Mesenchymal stem cells (MSC) play a crucial role in maintaining balance and promoting tissue repair, but aging impairs their function and regenerative capacity, leading to age-related diseases like osteoporosis [2]. - Mitochondrial dysfunction is a significant feature of aging MSC, characterized by mitochondrial homeostasis disruption, including impaired mitophagy and accumulation of dysfunctional mitochondria [2][9]. Group 2: Nanomedicine Development - The research team developed EM-eNM based on the structure and function of ATP synthase, a key enzyme in energy generation, to restore vitality in aging MSC and prevent skeletal aging [7]. - EM-eNM can penetrate the mitochondria of aging bone marrow MSC, promoting mitochondrial fission, mitophagy, and glycolysis, thereby maintaining the stemness and pluripotency of BMMSC [9]. Group 3: Therapeutic Potential - Systemic administration of EM-eNM via tail vein injection selectively targets bone tissue, significantly reversing osteoporosis-related bone loss in aged mice while restoring the stemness and osteogenic potential of BMMSC in situ [9]. - The study highlights the potential of EM-eNM as a targeted therapy for alleviating cellular aging and age-related diseases [10].