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Core Viewpoint - Obesity is a health condition associated with excess fat accumulation, leading to various complications and comorbidities. GLP-1 receptor agonists have been approved for treating obesity and type 2 diabetes, demonstrating effectiveness in appetite reduction and food intake decrease [2][3]. Group 1: Efficacy of GLP-1 Receptor Agonists - GLP-1 receptor agonists like semaglutide and tirzepatide have shown weight loss of 15%-20% compared to placebo after 68 and 72 weeks of treatment, respectively [3]. - Despite their effectiveness, about half of the patients discontinue treatment within the first year due to gastrointestinal side effects and high costs [3]. - A clinical trial indicated that participants who continued semaglutide lost an average of 17.3% of their weight over 68 weeks, while those who switched to placebo regained approximately 6.9% of their weight [6]. Group 2: Challenges in Weight Maintenance - One of the biggest challenges in weight loss is maintaining the results, as many individuals experience weight regain after stopping treatment. Studies show that discontinuation of GLP-1 receptor agonists often leads to weight gain [5]. - After stopping semaglutide, 18% of patients regained their previous weight, and 26% regained more than 25% of their lost weight within a year [6]. Group 3: Treatment Duration and Strategies - It is recommended to continue treatment for at least 12 weeks before assessing effectiveness, with a suggested duration of 9 months to 1 year for consolidation therapy if significant weight loss is observed [7]. - Initial weeks of semaglutide treatment may lead to increased satiety and reduced food intake, although mild side effects like nausea may occur [10][11]. Group 4: Discontinuation and Monitoring - Gradual dose reduction is advised when discontinuing semaglutide to mitigate increased hunger sensations, especially for non-diabetic patients [12]. - Patients are encouraged to monitor their appetite and weight closely after stopping medication, and to maintain healthy eating habits and regular exercise to prevent weight rebound [14]. Group 5: Strategies to Prevent Weight Regain - Key strategies to prevent weight regain include altering dietary habits by reducing high-calorie foods and increasing protein and fiber intake to enhance metabolism [15]. - Incorporating strength training alongside aerobic exercises can help maintain weight loss by increasing muscle mass and metabolic rate [17]. - Adequate sleep is crucial for metabolic regulation, with 7-9 hours of sleep recommended for optimal health [18].