世界首例！中国团队将基因编辑猪肺成功移植人体

Core Viewpoint - The successful transplantation of gene-edited pig lungs into a human marks a significant milestone in xenotransplantation, potentially addressing the shortage of human organ donors [1][5][12]. Group 1: Research Achievement - A team led by Professor He Jianxing from Guangzhou Medical University successfully transplanted a gene-edited left lung from a Bama pig into a brain-dead patient, with the lung functioning for 9 days [1][12]. - The research was published on August 25 in the journal Nature Medicine, receiving high praise from international experts as a milestone in the field [2][4]. Group 2: Implications for Organ Transplantation - This achievement highlights the potential of gene-edited pig organs to be more compatible with human biology, which could alleviate the shortage of lung transplant donors [5][9]. - The global demand for organ transplants is increasing, and xenotransplantation is seen as a promising solution to the donor shortage crisis [9]. Group 3: Technical Details - The transplanted pig lung underwent six CRISPR gene edits to silence three genes that trigger immune responses and to introduce three human protein genes to reduce immune risks [14]. - Despite some immune response and organ damage observed, there was no immediate strong rejection of the gene-edited pig lung [6][17]. Group 4: Future Directions - The research team plans to optimize gene editing strategies and anti-rejection treatments to extend the survival and functionality of transplanted organs [13][26]. - Further studies are needed to address challenges related to organ rejection and infection before this procedure can be translated into clinical practice [26].