复旦大学发表最新Cell论文

Core Viewpoint - The current pathogen surveillance system primarily focuses on livestock and companion animals, neglecting non-traditional livestock and wild mammals, which poses a risk for cross-species transmission of pathogens and antibiotic resistance genes [2][3]. Group 1: Research Findings - A study published in the journal Cell identified a significant number of unrecorded viruses and bacteria in asymptomatic mammals, revealing extensive cross-species transmission [3][4]. - The research analyzed samples from 973 asymptomatic mammals, identifying 128 virus species (30 of which are newly discovered), 10,255 bacterial species (over 7,000 previously uncharacterized), 201 fungi, and 7 parasites [4][6]. - The study found that 13.3% of virus species coexisted in both farmed and wild mammals, including canine coronavirus in Asian black bears and Getah virus in rabbits [4][6]. Group 2: Antibiotic Resistance Insights - The research team observed 157 clinically significant antibiotic resistance genes (ARGs) in the microbiomes of farmed and wild mammals, with over 99% homology to ARGs found in human microbiomes [4][6]. - The presence of mobile genetic elements (MGE) alongside ARGs suggests a potential reservoir of antibiotic resistance in animal microbiomes, which could accelerate cross-species transmission due to antibiotic misuse [6][7]. Group 3: Implications for Public Health - The findings indicate that asymptomatic animals may serve as potential hosts for novel zoonotic viruses, highlighting the need for systematic monitoring of pathogens and antibiotic resistance genes at the "animal-environment-human" interface [6][7].