Cell子刊：薯条汉堡等超加工食品，影响男性生殖及心血管代谢健康

Core Viewpoint - The consumption of ultra-processed foods (UPF) is significantly increasing globally, which is linked to various negative health outcomes, particularly in male reproductive and metabolic health [2][4][10]. Group 1: Health Impacts of Ultra-Processed Foods - UPF consumption is associated with an increased risk of chronic diseases, including cardiovascular diseases, metabolic disorders, certain cancers, and mental health issues [2]. - A notable decline in male semen quality has been observed globally, with sperm counts decreasing by approximately 60% since the 1970s, potentially linked to the rise in UPF consumption [6]. - The recent study confirms that UPF negatively impacts male reproductive and cardiovascular metabolic health, regardless of caloric intake [4][10]. Group 2: Research Findings - The study utilized a controlled 2×2 crossover design to assess the effects of UPF on reproductive and metabolic health, indicating that the harmful effects of UPF are not solely due to increased caloric intake [6][8]. - Key hormonal levels involved in energy metabolism and sperm production, such as GDF15 and follicle-stimulating hormone (FSH), were found to be altered due to UPF consumption [7][8]. - There was a significant increase in serum levels of phthalates (cxMINP), which are endocrine disruptors, following UPF consumption, while lithium levels in plasma decreased, correlating with mood disorders and cognitive decline [7][8].