同济大学发表最新Cell子刊

Core Viewpoint - The research identifies homocysitaconate as a significant anti-inflammatory metabolite that increases during inflammation, reshaping methionine metabolism and inhibiting inflammatory responses [2][7]. Group 1: Research Findings - Homocysitaconate levels increase 152 times during inflammation, demonstrating anti-inflammatory effects [3]. - The mechanism involves homocysitaconate binding to the pro-inflammatory protein MARS, inhibiting its function and reshaping methionine metabolism [3][4]. - The study confirms that homocysitaconate acts as a homeostatic regulator through protein modification, providing new strategies for managing inflammatory complications [7]. Group 2: Therapeutic Implications - Homocysitaconate shows therapeutic effects in models of sepsis, high-fat diet-induced inflammation, and colitis [4]. - Supplementation with nicotinamide riboside or pyruvate can enhance the endogenous synthesis of homocysitaconate, targeting the MARS/NLRP3-N-homocysteinylation cascade to suppress inflammation [4][8].