减肥反弹背后的生物学真相：《自然》双重研究揭秘"曾胖标记"与炎症细胞如何联手破坏你的减重成果

Core Insights - The article emphasizes that weight loss is not merely about the numbers on the scale but involves significant changes in the underlying fat tissue, which can reverse aging processes in metabolic cells [7][9][10] - It highlights the persistent "memory" of inflammation in immune cells and fat tissue, which can lead to weight regain after initial weight loss [10][15][19] Group 1: Research Findings - A study published in July 2025 in Nature revealed that obesity accelerates the aging of metabolic and vascular cells in fat tissue, while weight loss can significantly reverse this premature aging [7] - The research indicates that while weight loss reduces inflammation, the immune system retains a "memory" of the previous obese state, which may contribute to weight regain [10][12] - The study focused on subcutaneous abdominal fat, linking it to metabolic disorders such as type 2 diabetes and hyperlipidemia, suggesting that understanding its dynamics is key to unlocking the health benefits of weight loss [8] Group 2: Mechanisms of Weight Loss - Weight loss not only reduces body weight but also transforms the structure and function of fat tissue towards a healthier state, involving complex immune regulatory mechanisms [10][15] - Despite improvements in local inflammation and reduced expression of inflammatory factors, some macrophages remain in a pre-activated state, posing a risk for future inflammation and weight regain [10][12] - Research shows that even two years after successful weight loss, fat cells retain changes from the obese state, leading to increased absorption of sugars and fats, which can accelerate fat accumulation upon re-exposure to high-calorie diets [15][19] Group 3: Experimental Evidence - Animal studies using C57BL/6J mice demonstrated that after weight loss, the fat tissue still exhibited increased macrophage presence and persistent gene expression changes associated with obesity [17][19] - The findings indicate that these "obesity memories" in fat cells can lead to abnormal responses to metabolic stimuli, contributing to the risk of weight regain and the recurrence of obesity-related metabolic diseases [19]