南昌大学最新Cell子刊论文：这款国产降糖药，可发挥多种抗衰老作用

Core Viewpoint - The global prevalence of type 2 diabetes is rapidly increasing, with an estimated 700 million people affected by 2045, posing a significant public health threat. Aging mechanisms are closely related to the progression of diabetes, and delaying aging may be crucial for improving diabetes and other age-related diseases [3][4]. Group 1: SGLT2 Inhibitors and Aging - Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are important anti-diabetic drugs that lower blood sugar by inhibiting glucose reabsorption in the kidneys. They also enhance lipid metabolism and ketone production, potentially mimicking caloric restriction (CR) and exerting anti-aging effects [3][4]. - SGLT2i can simulate the effects of caloric restriction without the need for strict dietary control, providing a more feasible alternative for anti-aging interventions in diabetic patients [4][5]. Group 2: Clinical Study Findings - A multicenter, randomized, double-blind, placebo-controlled study published in Cell Reports Medicine revealed that the SGLT2i drug Henagliflozin can extend telomere length and may exert anti-aging effects through various pathways, including the IGF-1 system, glucose metabolism, and immune function [5][6][9]. - In the clinical trial involving 150 type 2 diabetes patients, those treated with Henagliflozin showed significant increases in telomere length, insulin-like growth factor binding protein-3 (IGFBP-3) levels, and β-hydroxybutyrate levels, along with improved glucose metabolism [8][9]. - The study also indicated that Henagliflozin significantly increased granzyme B expression in cytotoxic T lymphocytes and showed trends of increased perforin expression, suggesting enhanced immune function [8][9]. Group 3: Implications and Future Research - The findings highlight the potential of SGLT2i in the anti-aging domain, with Henagliflozin receiving the highest score among nine FDA-approved drugs evaluated for anti-aging potential [6][9]. - However, there is still a lack of direct clinical data regarding the anti-aging effects of SGLT2i, indicating a need for further research in this area [6].