《Cell》震惊全球：中华神草化身燃脂魔弹，雷公藤红素或成减重界王者

Core Viewpoint - The research highlights Celastrol, a triterpenoid extracted from the root of Tripterygium wilfordii, as a promising anti-obesity agent that enhances leptin sensitivity and significantly reduces body weight in diet-induced obese (DIO) mice by up to 45% [6][8][19]. Summary by Sections Research Findings - The study conducted by Umut Ozcan's team at Harvard Medical School identified Celastrol through computer-aided drug screening as a potential anti-obesity molecule [6][8]. - Celastrol effectively suppresses appetite and prevents energy expenditure decline, demonstrating its role as a leptin sensitizer [8][19]. - In DIO mice, Celastrol treatment led to a weight reduction from 47.53±1.0g to 35.43±0.97g over 15 days, a decrease of 25.3% [12]. Mechanism of Action - Celastrol activates the leptin receptor-STAT3 signaling pathway in the hypothalamus, enhancing leptin's effects and reducing food intake [17]. - The compound also alleviates endoplasmic reticulum stress, contributing to its weight loss effects [17]. Experimental Results - In DIO mice, Celastrol administration resulted in a 79% reduction in daily food intake, with body weight stabilizing at 34.38±1.06g after three weeks [12]. - The study found that Celastrol did not affect body weight in leptin-deficient (ob/ob) or leptin receptor-deficient (db/db) mice, confirming its dependence on the leptin signaling pathway [14][15]. Potential for Clinical Application - The findings suggest that Celastrol could be developed as a novel anti-obesity drug, potentially becoming the first traditional Chinese medicine for weight loss [19]. - The research provides a new perspective and candidate for obesity treatment, emphasizing the need for further clinical studies [19].