Cell Metabolism：陈子江/赵涵/张玉青团队提出，多囊卵巢综合征本质上是生殖代谢紊乱疾病

Core Viewpoint - Polycystic Ovary Syndrome (PCOS) is primarily a reproductive metabolic disorder rather than just a reproductive disease, opening new pathways for intervention and prevention based on metabolic regulation [2][7]. Group 1: Overview of PCOS - PCOS affects approximately 10% to 13% of women globally and poses lifelong health threats from puberty to menopause and beyond [2]. - The condition is characterized by reproductive and metabolic abnormalities, including insulin resistance, obesity, and dyslipidemia, significantly increasing the risk of Type 2 Diabetes (T2D) and other metabolic diseases [5][14]. Group 2: Genetic and Epigenetic Factors - PCOS has a strong genetic and epigenetic basis, with evidence of familial clustering and transgenerational inheritance affecting both male and female offspring [5][11]. Group 3: Research Challenges - The coexistence of reproductive and metabolic abnormalities complicates the research and management of PCOS, with ongoing debates about its fundamental nature as a metabolic disorder with reproductive consequences or vice versa [6][14]. Group 4: Metabolic Dysfunction as a Key Driver - Recent studies highlight metabolic dysfunction, particularly obesity and insulin signaling, as critical factors in the pathophysiology of PCOS, suggesting that metabolic dysregulation is a key driver of the condition [6][7][14]. - The article emphasizes the need to understand PCOS as an endocrine metabolic disorder to reshape prevention and reversal strategies [7][14]. Group 5: Therapeutic Opportunities - Promising metabolic intervention strategies identified in preclinical and clinical studies include caloric restriction, GLP-1-based therapies, and bariatric surgery, which have shown efficacy in alleviating PCOS symptoms and potentially mitigating its hereditary aspects [14].