登上Cell子刊封面：上海交大团队揭示口腔细菌加重肠道疾病的新机制

Core Viewpoint - The study highlights the role of the oral symbiotic bacterium Veillonella in promoting Clostridioides difficile infection (CDI) in patients with Crohn's disease by inhibiting bile acid transport protein ASBT, leading to abnormal bile acid accumulation in the intestine [3][9]. Group 1: Disease Overview - Crohn's disease is a common inflammatory bowel disease (IBD) characterized by abdominal pain, diarrhea, and intestinal obstruction, affecting the entire digestive tract with a high postoperative recurrence rate of approximately 80% [2]. - The global prevalence of IBD was 0.75% as of 2020, projected to rise to 1.0% by 2030, with 37%-59% of IBD cases being Crohn's disease [2]. Group 2: Research Findings - The research published in Cell Host & Microbe indicates that Veillonella intestinal colonization promotes CDI in Crohn's disease patients [3]. - Veillonella parvula inhibits the expression of the bile acid transport protein ASBT, preventing bile acid reabsorption and causing abnormal bile acid accumulation in the intestine, which triggers CDI [9][12]. - The study found a correlation between the abundance of Veillonella and increased bile acid metabolism in Crohn's disease patients, suggesting that the presence of bile acids can facilitate the germination of C. difficile spores [9][12].