Nature系列综述：刘光慧等全面概述人类和非人灵长类衰老标志物

Core Viewpoint - The article discusses the importance of identifying aging biomarkers in primates to enhance understanding of human aging and to provide interventions for age-related conditions [2][3]. Group 1: Overview of Aging and Biomarkers - Aging is characterized by gradual loss of physiological functions and increased disease risk, leading to higher mortality rates [5]. - With the global increase in life expectancy and aging populations, a systematic overview of aging issues is crucial for developing strategies to promote healthy aging and prevent age-related diseases [5]. - Non-human primates serve as invaluable models for studying aging due to genetic and physiological similarities with humans, bridging the gap between mechanistic insights and clinical applications [5][6]. Group 2: Importance of Biomarkers - Research on aging biomarkers is essential as they can quantify cellular or molecular damage and physiological decline, serving as indicators of biological age [6]. - Recent breakthroughs, such as specific DNA methylation patterns associated with biological age, have provided new hope for the field [6]. - The potential of primate aging biomarkers lies in their ability to facilitate early detection, intervention, and the development of therapeutic pathways in clinical practice [6][7]. Group 3: Current Research Landscape - Despite advancements, research on primate aging biomarkers remains fragmented, lacking a comprehensive integration of data across different biological levels [7]. - A unified framework for aging biomarkers in primates is necessary to enhance understanding of the aging process and to develop effective interventions against age-related diseases [7][13]. - The review aims to consolidate existing data on aging biomarkers at cellular, tissue, and organ levels, discussing their roles in cellular senescence, tissue degeneration, and systemic aging [13].